7660-25-5

Fructose can be used in animal modeling to create rat models of hyperuricemia and diabetes. In mice fed a 0% Fructose diet, portal vein (0.060±0.006 mM, overall average across all time points) and systemic (0.030±0.003 mM) Fructose concentrations do not change over time after feeding. In contrast, in wild-type mice, the portal vein concentration more than doubles from time (t)=0 to t=1 hour post-feeding (~0.13 mM). Similarly, systemic serum Fructose increases from 0.037 at t=0 to 0.13 mM one hour post-feeding. In the 20% group, fasting (t=0) serum Fructose levels in the portal vein and systemically are similar to the postprandial concentrations in 0% mice, suggesting that baseline Fructose concentrations during fasting are not affected by diet. At the same dietary conditions, time, and sampling site, serum Fructose concentrations in KHK^-/- mice are 5 to 100 times higher than in wild-type mice. The mean (across all time points) portal vein and systemic glucose concentrations in mice fed 20% Fructose are approximately 3 (P=0.004) and 2 (P=0.04) mM higher, respectively, compared to mice fed 0% Fructose. Systemic Fructose concentrations in KHK^-/- mice fed 20% Fructose are about three times higher than in mice fed glucose, whereas systemic Fructose concentrations in wild-type mice fed Fructose are similar to those fed glucose^[2].