758-96-3

802294-64-0

68-12-2

758-96-3

GENERAL METHOD: Carboxylic acid (0.3 mmol), catalyst (5 mol%), Xantphos (10 mol%), K2S2O8 (2 equiv.) and N,N-dimethylformamide (2 mL) were added to a 20 mL reaction tube. After sealing the reaction tube, the mixture was stirred at 160 °C for 12 h or until the reaction was complete. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with hexane-ethyl acetate (1:1, v/v) as eluent.