Description
2,2-Dimethylbutyric acid is the intermediate of crucial importance in producing cardiovascular drugs, such as Simvastatin and agricultural chemicals, miticide spiral shell mite ester. It can also be used for rubber, dyestuff, etc. industries simultaneously. All 2,2-Dimethylbutyric acid production processes are that primary isoamyl alcohol and formic acid react under sulfuric acid catalysis. This technique's shortcoming is to produce a large amount of Waste Sulfuric Acids.
Chemical Properties
Colorless to light yellow or light green liquid
Uses
2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies.
Definition
ChEBI: A branched-chain fatty acid and metabolite of the lactone prodrug simvastatin, whose sodium salt is potentially useful for the treatment of thalassaemias and haemoglobinopathies.
Synthesis
Adding 15 to 25 parts by weight of solid acid catalyst, 150 to 170 parts by weight of isoamyl alcohol, and 15 to 20 parts by weight of sulfuric acid into a high-pressure reactor, evenly stirring to obtain a reaction mixture, introducing nitrogen gas into the reactor, introducing CO into the reaction mixture at a temperature of 85 to 90 ℃, maintaining a pressure of 0.1 to 0.15 MPa until the pressure starts to rise; cooling to the room temperature, introducing nitrogen gas into the reactor to replace the CO gas, discharging materials from the reactor, filtering to obtain the solid acidified catalyst; adding 5 to 15 parts by weight of saturated sodium chloride water solution into the filtrate, evenly stirring, allowing the system to stand still, removing the lower water layer, and rectifying the upper oil layer to obtain the product 2,2-Dimethylbutyric acid.
