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Bitter orange is grown in Asia and parts of the Mediterranean.

Bitter orange has been used traditionally as a sedative, an appetite stimulant, an insecticide for mosquitos, and for Tinea infections and dyspepsia. It is also used for anemia, kidney/bladder disorders, heart, and circulation. Topically bitter orange is used for inflammation of eyelids, conjunctivae, muscle pain, rheumatic pain, and phlibitis.

Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus aurantium, Rutaceae.