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5-Carboxymethylaminomethyluridine or cmnm5U, is a modification of tRNA responsible for restricting codon-anticodon wobbling and recognition of purine-ending codons. This modification can be catalyzed by the action of GidA and MnmE enzymes on uridine.

ChEBI: A derivative of uridine, bearing an additional carboxymethylaminomethyl substituent at position 5 on the uracil ring.