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68181-17-9

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Identification

Name
SPDP
CAS
68181-17-9
Synonyms
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-HYDROXY-SUCCINIMIDE ESTER
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER
3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU
3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU
N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE
SPDP
SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE
succinimidyl3-(2-pyridyldithio)propionate(spdp)
1-[1-oxo-3-(2-pyridyldithio)propoxy]pyrrolidine-2,5-dione
3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM
2,5-Pyrrolidinedione, 1-1-oxo-3-(2-pyridinyldithio)propoxy-
3-(2-PYRIDYLDITHIO)-PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
3-(Pyridin-2-yldisulfanyl)-propionic acid-OS
N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP
1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione
3-(2-Pyridyldithio)propionic acid 2,5-dioxo-1-pyrrolidinyl ester
3-[(2-Pyridinyl)dithio]propionic acid succinimidyl ester
3-[(2-Pyridyl)dithio]propionic acid succinimidyl ester
N-[3-(2-Pyridyldithio)propionyloxy]succinimide
EINECS(EC#)
269-034-3
Molecular Formula
C12H12N2O4S2
MDL Number
MFCD00009636
Molecular Weight
312.36
MOL File
68181-17-9.mol

Chemical Properties

Appearance
White Solid
Melting point 
84-86 °C(lit.)

mp 
84-86 °C(lit.)

Boiling point 
465.9±55.0 °C(Predicted)
density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
−20°C

solubility 
acetone: 50 mg/mL

pka
1.76±0.19(Predicted)
form 
powder

Usage
A heterobifunctional cross-linker
BRN 
1548137
InChIKey
JWDFQMWEFLOOED-UHFFFAOYSA-N
CAS DataBase Reference
68181-17-9(CAS DataBase Reference)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
WGK Germany 
3


1-10
HS Code 
29333990

Hazard Information

Chemical Properties
White Solid
Uses
A heterobifunctional cross-linker
Uses
Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds.
General Description
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.

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