68124-04-9

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Used for content determination/identification/pharmacological experiments, etc.

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.

Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.

Akt

p38

Bcl-2

Caspase-9

Caspase-3

PARP-1