66675-22-7

131543-46-9

421-53-4

66675-22-7

General procedure for the synthesis of 2-(trifluoromethyl)-1H-imidazole from the compound (CAS:131543-46-9) and 2,2,2-trifluoroethane-1,1-diol: 20 mL of ammonia aqueous solution was added to a three-necked flask at room temperature and stirred. Subsequently, 5 mL of trifluoroacetaldehyde hydrate was mixed with 5 mL of glyoxal and slowly added dropwise to the aqueous ammonia solution, and the reaction was carried out for 2 hours at room temperature. After the reaction was completed, 20 mL of ethyl acetate was added for extraction for 30 minutes. The ethyl acetate layer was separated and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give a final 4.2 g of brown oily product, 2-(trifluoromethyl)-1H-imidazole.