ChemicalBook CAS DataBase List 66-97-7

66-97-7

Name	Psoralen
CAS	66-97-7
EINECS(EC#)	200-639-7
Molecular Formula	C11H6O3
MDL Number	MFCD00010520
Molecular Weight	186.16
MOL File	66-97-7.mol

Synonyms

7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE 7h-furo[3,2-g]benzopyran-7-one FICUSIN FURO[3,2-G]BENZOPYRAN-7-ONE FURO[3,2-G]COUMARIN PSORALEN 2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, delta-lactone 2-Propenoicacid,3-(6-hydroxy-5-benzofuranyl)-,δ-lactone 3-(6-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone 5-Benzofuranacrylic acid, 6-hydroxy-, delta-lactone 6,7-Furanocoumarin 6-hydroxy-5-benzofuranacrylicacidbeta-lactone 6-hydroxy-5-benzofuranacrylicacidelta-lactone 7H-Furo[3,2-g]chromen-7-one Furo(2',3',7,6)coumarin furo(2’,3’,7,6)coumarin furo(2’,3’:7’,6)coumarin Furo(4',5',6,7)coumarin furo(4’,5’,6,7)coumarin furo(4’,5’:6,7)coumarin

Chemical Properties

Appearance	Crystalline Solid
Melting point	160-162 °C
Boiling point	280.64°C (rough estimate)
density	1.2477 (rough estimate)
refractive index	1.6310 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	neat
color	White to Off-White
Water Solubility	65.16mg/L(25 ºC)
Usage	Use as photochemical probe in biological systems
λmax	328nm(EtOH)(lit.)
Merck	13,8019
BRN	152784
InChI	1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
InChIKey	ZCCUUQDIBDJBTK-UHFFFAOYSA-N
SMILES	O=C1Oc2cc3occc3cc2C=C1
LogP	1.670
CAS DataBase Reference	66-97-7(CAS DataBase Reference)
NIST Chemistry Reference	7H-furo[3,2-g][1]benzopyran-7-one(66-97-7)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P280-P301+P312+P330-P302+P352
Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
WGK Germany	3
RTECS	LV0944000
F	8-10
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Skin Sens. 1
Hazardous Substances Data	66-97-7(Hazardous Substances Data)

Hazard Information

Chemical Properties

Crystalline Solid

Uses

As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).

Uses

Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.

Uses

Use as photochemical probe in biological systems

Definition

ChEBI: The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 6735, 1984 DOI: 10.1021/ja00334a044
Synthetic Communications, 37, p. 63, 2007 DOI: 10.1080/00397910600978093

Biochem/physiol Actions

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

storage

Store at 4°C

Questions And Answer

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

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Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

China Langchem Inc.

Telephone0086-21-58956006

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm

Aktin Chemicals, Inc.

Telephone86-28-85159085

Websitehttp://www.aktinchem.com

Shenzhen Sungening Bio-Tech Co., Ltd

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Websitehttp://www.sungening.com/en

Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

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BioBioPha Co., Ltd.

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Chengdu Climax Biotech Co., Ltd.

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Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

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66-97-7

Chemical Properties

Safety Data

Hazard Information

Chemical Properties

Uses

Uses

Uses

Definition

Synthesis Reference(s)

Biochem/physiol Actions

storage

Questions And Answer

Description

References

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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