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Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM[1].

ChEBI: 2-Methyl-5-(2-thienyl)-3-furoic acid is a furoic acid.

Jedi2 is an activator of the mechanosensitive Piezo1 channel th at binds at a different place from Yoda1. It exhibits long-range allosteric gatingactivating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.

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[1] Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300. DOI:10.1038/s41467-018-03570-9