ChemicalBook CAS DataBase List 65052-63-3

65052-63-3

Name	Cefetamet hydrochloride
CAS	65052-63-3
EINECS(EC#)	675-838-9
Molecular Formula	C20H26ClN5O7S2
MDL Number	MFCD00864931
Molecular Weight	548.03
MOL File	65052-63-3.mol

Synonyms

(6R,7R)-7-[2-(2-AMINO-THIAZOL-4-YL)-2-METHOXYIMINO-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID CEFETAMET CEFETAMET ACID CEFETAMET PIVOXIL HCL CEFETAMET PIVOXIL HYDROCHLORIDE DEACETOXYCEFOTAXIME Ceftamet acid Cefetametacid,Cefetamet,Deacetoxycefotaxime Ceftamet (6R,7R)-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride Cefetamet hydrochloride (6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid [6R-[(6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefyl Globocef LY-097964 Ro．15-8074：Ro-15-8075 (6R,7R)-7-[[(Z)-(2-Aminothiazole-4-yl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid FR-13300 LY-97964

Chemical Properties

Melting point	>178°C (dec.)
density	1.83±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form	Solid
pka	3.11±0.50(Predicted)
color	White to Off-White
Stability:	Hygroscopic
CAS DataBase Reference	65052-63-3(CAS DataBase Reference)

Safety Data

HS Code

2941906000

Raw materials And Preparation Products

Hazard Information

Description

Ceftazidime hydrochloride is an oral third-generation cephalosporin, which has the same antibacterial activity against gram-positive bacteria as cefixime, and is superior to cefaclor, especially against Streptococcus pneumoniae and Streptococcus pyogenes. It has obvious antibacterial activity against a variety of gram-negative bacteria such as Escherichia coli, Proteus, Klebsiella pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae, especially against Serratia, indole-positive Proteus, Enterobacter The antibacterial activity of Citrobacter and Citrobacter was significantly enhanced.

Uses

Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.

Uses

Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.

Definition

ChEBI:Cefetamet is a cephalosporin compound having methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups; a cephalosporin antibiotic active against Neisseria gonorrhoeae.

Antimicrobial activity

A semisynthetic cephalosporin formulated for oral use as the prodrug ester, cefetamet pivoxyl. It is less active than cefaclor and cefadroxil against Staph. aureus, but as active against streptococci and more active against enterobacteria, H. influenzae and N. gonorrhoeae, including β-lactamase-producing strains. L. monocytogenes, C. difficile, Sten. maltophilia and Burk. cepacia are all resistant. It is resistant to hydrolysis by common plasmid-mediated enzymes.
The absolute bioavailability is about 50%. The plasma peak is delayed by food. Binding to plasma protein is about 20%. The volume of distribution approximates to the extracellular water. It is excreted into urine with a half-life of 2–2.5 h, principally in the glomerular filtrate. Elimination is linearly related to creatinine clearance. Side effects and uses are similar to those of other group 5 cephalosporins.

storage

Store at -20°C

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