Tigloyl-CoA (Tiglyl-coenzyme A) is an intermediate product of isoleucine metabolism. Tigloyl-CoA is an inhibitor of N-acetylglutamate synthetase[1].
Definition
ChEBI: 2-methylcrotonoyl-CoA is a 2-enoyl-CoA and a monounsaturated fatty acyl-CoA. It is functionally related to a but-2-enoyl-CoA and a tiglic acid. It is a conjugate acid of a 2-methylcrotonoyl-CoA(4-).
References
[1] Coude FX, et al. Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia. J Clin Invest. 1979 Dec;64(6):1544-51. DOI:10.1172/JCI109614
