ChemicalBook CAS DataBase List 60842-46-8

60842-46-8

Name	FLUORESCEIN ISOTHIOCYANATE-DEXTRAN
CAS	60842-46-8
Molecular Formula	C11H12N2S.HCl
MDL Number	MFCD00131092

Chemical Properties

storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, slightly hazy, orange
form	powder to crystaline
color	Light yellow to Yellow to Orange
biological source	synthetic (organic)
Water Solubility	water: 25mg/mL, cloudy to hazy, yellow to orange

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
WGK Germany	3
F	3
HS Code	2929100090
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Hazard Information

Chemical Properties

Dextran labeled with fluorescein isothiocyanate

Uses

water soluble cellulase substrate

General Description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. However, other methods indicate branches of greater than 50 glucose units exist. Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. Lower MW dextrans will exhibit slightly less branching and have a more narrow range of MW distribution. Dextrans with MW greater than 10,000 behave as if they are highly branched. As the MW increases, dextran molecules attain greater symmetry. Dextrans with MW of 2,000 to 10,000, exhibit the properties of an expandable coil. At MW below 2,000, dextran is more rod-like. The MW of dextran is measured by one or more of the following methods: low angle laser light scattering, size exclusion chromatography, copper-complexation and anthrone reagent colorometric reducing-end sugar determination and viscosity.

Biological Activity

FITC-Dextran serves as a versatile fluorescent tracer extensively used in biological and physiological research. Its primary actions encompass the assessment of permeability in biological barrierssuch as the blood-brain barriercell membranesand vascular walls. It is also utilized to investigate cellular uptake mechanismsendocytosisand cell junction permeabilityfocussing on essential cellular processes. FITC-Dextran aids in measuring blood flowvascular drainageand renal eliminationproviding insights into microcirculation and capillary dynamics. Furtherthis marker is also instrumental in understanding tissue and organ characteristics and can serve as a valuable tool for tracing moleculescontributing to the exploration of a wide array of biochemical phenomena.

in vivo

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
For intestinal barrier function assay^[5]
1. Fast mice for 4 h.
2. Orally gavage mice with FITC-Dextran MW 4000 (0.6 mg/g).
3. Measure fluorescence intensity of plasma in 4 h (excitation nm/emission 520 nm).

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