6080-33-7

Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.

White Solid

Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.

NF-κB; μ Opioid Receptor/MOR

Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]

[1] QUANXING WANG  Xiao K L. Immunosuppressive and anti-inflammatory activities of sinomenine[J]. International immunopharmacology, 2011, 11 3: Pages 373-376. DOI: 10.1016/j.intimp.2010.11.018
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[5] KRITIKA KESARWANI  Rajiv G. Bioavailability enhancers of herbal origin: An overview[J]. Asian Pacific journal of tropical biomedicine, 2013, 3 4: Pages 253-266. DOI: 10.1016/s2221-1691(13)60060-x
[6] ZHEN LIU. Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression.[J]. PLoS ONE, 2014: e98560. DOI: 10.1371/journal.pone.0098560