Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis.
1 It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events.
1,2,3,4 Sinomenine also impairs signaling through NF-
κB, resulting in immunosuppression as well as reduced inflammation and pain.
3,1 It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-
glycoprotein.
5,6 
