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Prostaglandin J₂ (PGJ₂) is formed from PGD₂ by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ₂ inhibits platelet aggregation with an IC₅₀ of about 5-10 nM. PGJ₂ has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ₂ and not the parent compound itself.

PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity.

ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).