ChemicalBook CAS DataBase List 591778-68-6

591778-68-6

Name	CP 640186
CAS	591778-68-6
Molecular Formula	C30H35N3O3
MDL Number	MFCD25976696
Molecular Weight	485.62
MOL File	591778-68-6.mol

Chemical Properties

Boiling point	721.1±60.0 °C(Predicted)
density	1.245±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form	A crystalline solid
pka	8.07±0.40(Predicted)
color	Light yellow to light brown

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P264-P280-P305+P351+P338-P337+P313

Hazard Information

Uses

CP 640186 can be used to regulate porcine reproductive and respiratory syndrome virus infection via the AMPK-?ACC1 signaling pathway.

Definition

ChEBI: (3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine is a member of anthracenes, a member of morpholines, a member of bipiperidines and a N-acylpiperidine.

in vivo

CP-640186 (oral gavage; 4.6-21 mg/kg; once) demonstrates acute efficacy^[1].
CP-640186 (intravenous injection and oral gavage; Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once) shows lowe drug exposure in the rat than the ob/ob mouse at equal doses^[1].
CP-640186 (oral gavage; 100 mg/kg; once) treatment shows a complete shift from carbohydrate utilization to fatty acid utilization as a source of energy at high exposure level^[1].

Animal Model:	Male ob/ob mice^[1]
Dosage:	4.6-21 mg/kg
Administration:	Oral gavage; 4.6-21 mg/kg; once
Result:	Demonstrated acute efficacy for up to 8 h after oral administration, exhibiting ED₅₀ values of 4.6, 9.7, and 21 mg/kg, at 1, 4, and 8 h, respectively, after treatment.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg
Administration:	Intravenous injection and oral gavage; Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once
Result:	Showed a plasma half-life of 1.5 h, a bioavailability of 39%, a Cl_p of 65 ml/min/kg, a V_dss of 5 liters/kg, an oral T_max of 1.0 h, an oral C_max of 345 ng/mL, and an oral AUC_0-∞ of 960 ng?h/mL.

Animal Model:	Male ob/ob mice^[1]
Dosage:	Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg
Administration:	Intravenous injection and oral gavage; Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once
Result:	Showed a plasma half-life of 1.1 h, a bioavailability of 50%, a Cl_p of 54 ml/min/kg, an oral T_max of 0.25 h, an oral C_max of 2177 ng/mL, and an oral AUC_0-∞ of 3068 ng?h/mL.

Animal Model:	Twenty male Sprague-Dawley rats (350-400 g) fasted and then refed a high sucrose diet for 2 days; additional eight rats fasted for 24 h^[1]
Dosage:	100 mg/kg
Administration:	Oral gavage; 100 mg/kg; once
Result:	Resulted in time-dependent reductions in RQ (a ratio of CO₂ production to O₂ consumption) of up to 64%.

storage

Store at -20°C

Spectrum Detail

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