59-97-2

Pale Yellow Crystalline Solid

Priscoline,Ciba,US,1948

a-adrenergic antagonist. A peripheral vasodilator

adrenergic blocker

Αn α-adrenergic antagonist. A peripheral vasodilator.

ChEBI: Tolazoline hydrochloride is a member of benzenes.

The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.

Tolazoline is INN and BAN.

Vasodilator

flipping of lips); piloerection; clear lacrimal & nasal discharge; muscle fasciculations; apprehensiveness Uses/Indications Tolazoline is approved and indicated for the reversal of effects associated with xylazine in horses. It has also been used for this purpose in a variety of other species as well, but less safety and efficacy data is available.
In humans, the primary uses for tolazoline are: treatment of persistent pulmonary hypertension in newborns, adjunctive treatment and diagnosis

Store at -20°C