ChemicalBook CAS DataBase List 570406-98-3

570406-98-3

Name	AKR-501
CAS	570406-98-3
EINECS(EC#)	1312995-182-4
Molecular Formula	C29H34Cl2N6O3S2
MDL Number	MFCD18633249
Molecular Weight	649.65
MOL File	570406-98-3.mol

Synonyms

YM477 E 5501 AKR-501 AS 1670542 AVATROMBOPAG AKR-501 USP/EP/BP Crenolanib Besylate Avatrombopag (AKR-501) Avatrombopag(AS1670542) Avatrombopag Base,Avatrombopag AKR-501; YM477; E5501; AS 1670542 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbo 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl]-2-pyridyl]piperidine-4-carboxylic acid 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid 1-[3-Chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-

Chemical Properties

density	1.440
storage temp.	Storage temp. 2-8°C
solubility	DMSO:27.33(Max Conc. mg/mL);42.07(Max Conc. mM)
form	A crystalline solid
pka	3.04±0.70(Predicted)
color	White to off-white
InChIKey	OFZJKCQENFPZBH-UHFFFAOYSA-N
SMILES	N1(C2=NC=C(C(NC3=NC(C4SC=C(Cl)C=4)=C(N4CCN(C5CCCCC5)CC4)S3)=O)C=C2Cl)CCC(C(O)=O)CC1

Safety Data

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P280-P305+P351+P338-P310

Hazard Information

Description

Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.

Uses

Avatrombopag is used to treat thrombocytopenia (a low number of platelets [type of blood cell needed for blood clotting]) in people with chronic (ongoing) liver disease. It is also used to treat thrombocytopenia in people with chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood).

Mechanism of action

Avatrombopag is in a class of medications called thrombopoietin (TPO) receptor agonists. It works by causing the body to produce more platelets.

in vivo

Avatrombopag (0.3-3 mg/kg; p.o.; daily for 14 days) increases the number of human platelets in NOD/SCID mice transplanted with human FL CD34⁺ cells^[1].

Animal Model:	NOD/SCID mice (transplanted with human FL CD34+cells)^[1]
Dosage:	0.3, 1, and 3?mg/kg
Administration:	P.o.; daily for 14 days
Result:	Dose-dependently increased the number of human platelets, resulting in approximately a 2.7‐fold increase at 1 mg/kg/d and a 3.0-fold increase at 3 mg/kg/d on day 14 after the start of administration.

target

TPO receptor

IC 50

IC 50 value is 3.3 nM.

Spectrum Detail

Supplier

Jinan chenghui-shuangda chemical co.,ltd.

Telephone 13256107535

Websitehttps://www.jinanande.com

Jinan XinKe Pharmaceutical Technology Co., Ltd.

Telephone0531-88259693 18660188356

Websitehttp://www.zisonpharm.cn/

Pharmalego

Telephone18321033991 13472578225;

Websitehttps://cn.pharmalego.com/

Shanghai Boyle Chemical Co., Ltd.

Telephone

Websitehttp://www.boylechem.com

Beijing Ouhe Technology Co., Ltd

Telephone13552068683 13522913783

Websitehttp://www.ouhetech.cn/

Daicel Chiral Technologies (China)CO.,LTD

Telephone021-50460086-9 15921403865

Websitehttp://www.daicelchiraltech.cn/reagents/Default.aspx

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

China Nobel Chem Co., Limited

Telephone+86(0)21 60484900

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15874/0_EN.htm

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810 18652991625

Website

TargetMol Chemicals Inc.

Telephone021-021-33632979 15002134094

Websitehttps://www.targetmol.cn/

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

Shanghai Kewel Chemical Co., Ltd.

Telephone021-64609169 18901607656

Websitehttp://www.kewelchem.com/

Intelligence Pharm Science(Shanghai) Co., Ltd.

Telephone021-57898186

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16931/0_EN.htm

Artis Biotech Co. Ltd.

Telephone18108108965 18108108965

Websitehttps://artis-standards.com/

Chengdu Ainahua Chemicals Co., Ltd.

Telephone028-86612776; 13699069380

Websitehttps://www.chemicalbook.com/supplier/10130892/

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 13636370518

Websitehttps://www.shyuanye.com

Cangzhou Enke Pharma-tech Co., Ltd.

Telephone0317-5296180 15533709196

Websitehttp://www.enkepharma.com/

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