570407-42-0

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is a valuable organic compound that could be used as an intermediate to synthesize thrombopoietin

Avatrombopag Maleate

4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is synthesize from the reacton of 4- (4-Chloro-2-thienyl) -5-bromo-2-thiazolylamine with cyclohexylpiperazine. The reaction mixture was extracted with water and EtOAc. The combined organic phases were washed with distilled water and brine and dried to afford 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine.