56525-42-9

71-23-8

162976-69-4

934-32-7

623-96-1

56525-42-9

The general procedure for the synthesis of 2-aminobenzimidazole, propyl carbonate and methylpropyl carbonate from n-propanol and compounds (CAS:162976-69-4) is as follows: amide-containing compounds having a (benzo)imidazole-2-yl group can be subjected to catalytic directional cleavage reactions with alcohol nucleophilic reagents in the presence of a metal catalyst. Specific embodiments are described in Scheme ES: using 10.0 mol% Zn(OAc)2-2H2O as a catalyst, 1.0 equivalent of ACDG-NH-C(O)-R3 (21d), and 30.0 equivalents of propanol (under sealed conditions) for a reaction time of 24 hr; wherein R is a 1H-benzo[d]imidazol-2-yl group, and R3 is an OMe. Reaction products The yields were determined by NMR analysis using TMB as an internal standard: 0% for unreacted 21d, 61% for 2-aminobenzimidazole (20d), 40% for methylpropyl carbonate (14c) and 22% for dipropyl carbonate (14d).