Chemical Properties
white powder
Uses
hepatoprotectant, t-glutaminase inhibitor, heat shock protein promoter, caspase inhibitor
Uses
sulfhydryl modifying reagent and heparin antagonist
Synthesis
Weigh 864g of composite glue, 1620g of water, 4320g of cysteamine hydrochloride, 120 mesh powdered silica 2376g and 1620g of ammonia caseic acid, add the composite glue to water, add cysteamine hydrochloride, stir well, placed at room temperature for 2h,
storage
room temperature (desiccate)
Purification Methods
Recrystallise the salt by dissolving in EtOH containing a few drops of dry EtOH/HCl, filtering and adding dry Et2O. The solid is dried in a vacuum and stored in a dry and dark atmosphere. It has been recrystallised from EtOH (solubility: 1g in 60mL of boiling EtOH) or MeOH (plates). The free base has b 90-Purification of Biochemicals — Amino Acids and Peptides 100o/0.001mm, 106-108o/5mm and 135-136o/760mm, d 4 1.1559, n D 1.5720. [Verly & Koch Biochem J 58 663 1954, Gonick et al. J Am Chem Soc 76 4671 1954, Jackson & Block J Biol Chem 113 137 1936.] The dihydrobromide has m 238-239o (from EtOH/Et2O) [Viscontini Helv Chim Acta 36 835 1953]. [Beilstein 4 H 287, 4 IV 1578.]
