ChemicalBook CAS DataBase List 56-92-8

56-92-8

Name	Histamine dihydrochloride
CAS	56-92-8
EINECS(EC#)	200-298-4
Molecular Formula	C5H11Cl2N3
MDL Number	MFCD00012703
Molecular Weight	184.07
MOL File	56-92-8.mol

Synonyms

1H-IMIDAZOLE-4-ETHANAMINE DIHYDROCHLORIDE 2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE 2HCL 2-(1H-IMIDAZOL-4-YL)ETHYLAMINE DIHYDROCHLORIDE 2-[4-IMIDAZOLYL]-ETHYLAMINE 2HCL 2-(4-IMIDAZOLYL)ETHYLAMINE DIHYDROCHLORIDE 2-[4-IMIDAZOYL]-ETHYLAMINE DIHYDROCHLORIDE HISTAMINE 2HCL HISTAMINE DIHCL HISTAMINE DIHYDROCHLORIDE HISTAMINI DIHYDROCHLORIDUM TIMTEC-BB SBB003722 bichlorhydrated’histamine edihydrochlorideAvailablefrom1kgto100kg. histaminedichloride OCHLORIDE 2-imidazol-4-ylethylamine dihydrochloride HISTAMINE DICHLORHYDRATE Histamine-alpha,alpha,??d4?HCl)2 HISTAMINE DIHYDROCHLORIDE, PH EUR HISTAMINE DIHYDROCHLORIDE (1H-IMIDAZOLE-4-ETHAN

Chemical Properties

Appearance	white powder
Melting point	249-252 °C(lit.)
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	powder
color	white to off-white
Stability:	Stable. Incompatible with strong oxidizing agents.
Water Solubility	SOLUBLE
Detection Methods	T,NMR
Merck	14,4719
BRN	3624116
InChI	InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChIKey	PPZMYIBUHIPZOS-UHFFFAOYSA-N
SMILES	C1(N=CNC=1)CCN.Cl.Cl
CAS DataBase Reference	56-92-8(CAS DataBase Reference)
EPA Substance Registry System	56-92-8(EPA Substance)

Safety Data

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H317-H319-H334-H335
Precautionary statements	P280-P302+P352-P305+P351+P338
Hazard Codes	Xn,Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . R42/43:May cause sensitization by inhalation and skin contact . R42:May cause sensitization by inhalation. R22:Harmful if swallowed. less more
Safety Statements	S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S37:Wear suitable gloves . S36/37:Wear suitable protective clothing and gloves . less more
RIDADR	3335
WGK Germany	2
RTECS	MS1575000
F	1-8-9
Hazard Note	Irritant
TSCA	Yes
REACH Registrations	Active
HazardClass	IRRITANT
HS Code	29332900
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3

Hazard Information

Chemical Properties

white powder

Uses

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Uses

Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter.

General Description

Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo .

Biochem/physiol Actions

Synthesis

A method for synthesizing histamine dihydrochloride was carried out as follows: 15 g of L-histidine, 1.5 g of cuprous bromide, 4 ml of p-methylacetophenone, and 120 ml of methylcyclohexanol were added to a 200 ml flask equipped with mechanical stirring an

storage

Room temperature (desiccate)

Purification Methods

The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

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