ChemicalBook CAS DataBase List 559-70-6

559-70-6

Name	beta-Amyrin
CAS	559-70-6
EINECS(EC#)	209-204-6
Molecular Formula	C30H50O
MDL Number	MFCD00017381
Molecular Weight	426.72
MOL File	559-70-6.mol

Chemical Properties

Melting point	187-190°C
alpha	D19 +99.8° (c = 1.3 in benzene)
Boiling point	bp0.8 260°
density	0.9600 (rough estimate)
refractive index	1.4910 (estimate)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	15.18±0.70(Predicted)
color	White to Off-White
Optical Rotation	+9120 (c 1.23, CHCl3)
BRN	2063468
Cosmetics Ingredients Functions	SKIN CONDITIONING - MISCELLANEOUS SKIN PROTECTING
InChIKey	JFSHUTJDVKUMTJ-QHPUVITPSA-N
LogP	10.481 (est)
CAS DataBase Reference	559-70-6(CAS DataBase Reference)
NIST Chemistry Reference	«BETA»-amyrin(559-70-6)

Safety Data

Hazard Codes	Xi
Risk Statements	R22:Harmful if swallowed. less more
Safety Statements	S22:Do not breathe dust . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
WGK Germany	3
F	10-23

Hazard Information

Uses

nociceptive

Definition

ChEBI: A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.

Biological Activity

Triterpene th at has broad-spectrum analgesic properties for which the underlying mechanism is poorly understood.

in vivo

β-Amyrin (4 mg/kg, p.o., daily, 5 days) ameliorates object recognition memory deficit and neurogenesis impairments in the hippocampus of Aβ-induced AD model mice^[1].
β-Amyrin (20-100 μg, i.p.) inhibits carrageenan-induced paw edema of rats^[2].
β-Amyrin (20-80 mg/kg, i.g., daily, 5 days) has a potent efficacy in protecting against BLM-induced mice pulmonary fibrosis via suppressing inflammatory response and oxidative stress^[3].
Pharmacokinetic parameters of β-Amyrin in rats

	β-Amyrin standard IV (group 3)	β-Amyrin standard oral dose (group 2)
Dose (mg kg?1)	1	3	300 (equivalent of 3mg kg?1 β-amyrin)
V (ml kg?1)	1317
AUC_{0→24 h} (min μg ml?1)	411	10.6	47.3
Cl (ml min?1 kg?1)	2.04
t_1/2λZ (h)	10.2	10.3	8.3
MRT_{0→24 h} (h) (h)	8	8.5	8.7
C_max (ng ml?1) (h) (h)		18.7	75
t_max (h)	-	3 (n = 2) or 5 (n = 1)	3 (n = 3) or 5 (n = 1)
F (%)		0.86	3.83

Animal Model:	Male CD-1 mice, 26-28 g, 6 weeks old. 5 μL of Aβ was acutely injected into the left lateral ventricle by hand^[1].
Dosage:	4 mg/kg
Administration:	p.o., daily, 5 days
Result:	Increased number of transitions between the light and dark compartments. Increased the total exploration time on the light compartment of the apparatus and the time spent in open arms. Ameliorated the reduction of neurogenesis.

Animal Model:	Adult male rats of Sprague–Dawley strain, weighing 150-180 g. Carrageenan induces edema in the hind paw of the rat^[2].
Dosage:	20, 50, 100 μg/kg
Administration:	i.p.
Result:	Significant decreased edema by in a dose dependent manner.

Animal Model:	Adult male rats of Sprague–Dawley strain, weighing 150-180 g. Carrageenan induces Use Bleomycin (BLM) (HY-108345), 5mg/kg, one-time intratracheally injection, in 50μL saline per mouse to induce the marine model of pulmonary fibrosis^[3].
Dosage:	20, 40, 80 mg/kg
Administration:	i.g., daily, 5 days
Result:	Promoted the values of SO2 and PO2 and inhibited the value of PCO2. Significantly improved inflammatory cell infiltration, the thickened alveolar septum and the lesion collapses of the alveoli and formation of flaky lung tissue.

target

storage

Store at -20°C

Material Safety Data Sheet(MSDS)

Spectrum Detail

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