55658-71-4

Name	HU-580
CAS	55658-71-4
Molecular Formula	C23H32O4
Molecular Weight	372.5
MOL File	55658-71-4.mol

Synonyms

HU-580 Cannabidiolinsaeure-methylester Cannabidiolic Acid methyl ester Benzoic acid, 2,4-dihydroxy-3-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-6-pentyl-, methyl ester

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Chemical Properties

Boiling point	537.6±50.0 °C(Predicted)
density	1.081±0.06 g/cm3(Predicted)
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
pka	8.35±0.50(Predicted)

Safety Data

Symbol(GHS)	GHS02,GHS07
Signal word	Danger

Hazard Information

Uses

Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects[1][2][3].

IC 50

5-HT_1A Receptor

References

[1] Pertwee RG, et al. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol. 2018 Jan;175(1):100-112. DOI:10.1111/bph.14073
[2] Zhu YF, et al. An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. Br J Pharmacol. 2020 Jun;177(12):2712-2725. DOI:10.1111/bph.14997
[3] Murillo-Rodríguez E, et al.Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats. J Cannabis Res. 2021 Jul 12;3(1):31. DOI:10.1186/s42238-021-00081-1

Supplier

Shanghai Synchem Pharma Co., ltd

Telephone21-619849051-1 18521059765

Websitehttp://www.synchem-pharma.com

Jinan Cen Ben Medical Technology Co., Ltd

Telephone 14793566

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1779126/0_EN.htm

Shandong Dayou Pharmaceutical Research and Development Co., Ltd.

Telephonedayouchem@126.com 15165037910

Website

TargetMol

Telephone400-821-0310 15002144251

Websitehttps://www.targetmol.cn/

Guangzhou CATO Research Chemicals Inc.

Telephone+86-020-81960175-617 18520203721

Websitehttps://www.cato-chem.com/

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