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Herbicidin A is an adenine nucleoside antibiotic originally isolated from S. saganonensis that exhibits herbicidal activity, particularly against dicotyledonous plants. It prevents rice seed germination (MIC = 6.25 μg/ml) and completely protects young rice plants from X. oryzae-induced leaf blight when applied at 100 ppm. In HEK293 cells, herbicidin A inhibits TNF-α-induced NF-κB activity and induces cytotoxicity (IC₅₀s = 1.8 and 2.7 μM, respectively).

Herbicidin A is a chemical with antibacterial and herbicidal activity.

Herbicidin A is the major analogue of a family of adenosine nucleosides containing a complex tricyclic saccharide originally isolated from Streptomyces saganonensis, reported by researchers at Sankyo in 1976. Hebicidin A is a potent herbicide with selective activity against dicotyledonous plants. The mode of action and broader pharmacology of herbicidin A has received little attention due to its restricted availability.

[1] M ARAI. Herbicidins A and B, two new antibiotics with herbicidal activity. I. Producing organism and biological activities.[J]. Journal of Antibiotics, 1976, 29 9: 863-869. DOI: 10.7164/antibiotics.29.863
[2] H YOSHIKAWA  M T  Y Takiguchi. Terminal steps in the biosynthesis of herbicidins, nucleoside antibiotics.[J]. Journal of Antibiotics, 1983, 36 1: 30-35. DOI: 10.7164/antibiotics.36.30
[3] XINGYUN CHAI. Herbicidin Congeners, Undecose Nucleosides from an Organic Extract of Streptomyces sp. L-9-10[J]. Journal of Natural Products , 2014, 77 2: 227-233. DOI: 10.1021/np4006635