548756-68-9

PD 334581 is a MEK inhibitor that inhibits MEK activity in C26 colon carcinoma cells with an IC₅₀ value of 0.032 μM.

PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1.

MEK1

Store at -20°C

[1] JOSEPH S. WARMUS . 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 23: Pages 6171-6174. DOI: 10.1016/j.bmcl.2008.10.015