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• Description

  Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. Dyclonine belongs to a kind of oral anaesthetic. It is contained in the “Sucrets” as well as some kinds of Cepacol sore throat spray as an active ingredient. Dyclonine takes effect through reversibly binding to the activated sodium channels located on the neuronal membrane. This decreases the permeability of sodium across the neuronal membrane, further increasing the threshold for excitation. Overall, Dyclonine stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and further suppressing the subsequent conduction. This causes a transient and reversible anaesthetic effect in a local area of the body. ;

• Chemical Properties

  Dyclonine hydrochloride is a white crystalline powder possessing topical anesthetic properties characterized by rapid onset of effect, lack of systemic toxicity and a low index of sensitization.;

• Indications

  Dyclonine hydrochloride is a ketone derivative without an ester or amide linkage that may be used in patients who are allergic to the common anesthetics. Dyclonine offers advantages over other topical anesthetic agents.Extensive experience with the topical preparation has shown it to be effective and safe. As a topical anesthetic, dyclonine hydrochloride is available by prescription, and to patients it is available over-the-counter in Sucrets lozenges.
  Classification: Ketone.
  Available concentration: Formulated for use in dentistry as a 0.5% or 1% solution.
  Onset of action: Slow; may take up to 10 minutes to become effective. Duration: Average duration of 30 minutes; however, effects may last up to 1 hour.
  Maximum recommended dose: 200 mg (40 mL of 0.5% solution or 20 mL of a 1% solution).
  Metabolism/excretion: No information is available on the metabolism and excretion of dyclonine hydrochloride.
  Pregnancy/lactation: FDA Category C/Caution is recommended during lactation. ;

• Uses

  Dyclonine hydrochloride is used for the temporary relief of the following occasional mouth and throat symptoms: pain, minor irritation, sore mouth and sore throat. It is a sodium channel blocker and a HSP90 chaperone protein inhibitor. It shows local anesthetic effects in vivo and is orally active.;

• References

  https://en.wikipedia.org/wiki/Dyclonine
  https://pubchem.ncbi.nlm.nih.gov/compound/Dyclonine_hydrochloride#section=Top ;

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