Description
17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 .
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Uses
17(R)-Resolvin D4 (17(R)-RvD4) is the R-enantiomer of Resolvin D4. Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection[1].
Definition
ChEBI: Aspirin-triggered resolvin D4 is a member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17R-stereoisomer). It has a role as an anti-inflammatory agent, a human xenobiotic metabolite and a mouse metabolite. It is a resolvin, a secondary allylic alcohol, a triol and a hydroxy polyunsaturated fatty acid.
References
1. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals J. Exp. Med. 196(8),1025-1037(2002).
