52669-92-8

4-[4-(4-Chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]-1-(4-fluorophenyl)-1-butanone is a dehydrated metabolite of haloperidol that can be biotransfomed by humans to Haloperidol pyridinium (HPP+), a potential neurotoxic found in the brain.

ChEBI: 4-(4-(P-Chlorophenyl)-2,5,6-Trihydropyridino)-4'-Fluorobutyrophenone is an aromatic ketone.

Protein tyrosine phosphatasereceptor type S (PTPRS)/ PTPs localized on the cell surface plays a vital role in cell–cell and cell– extracellular matrix (ECM) interactionsand is implicated in the regulation of axon homeostasis and neuronal development. In additionPTPRS also has a crucial role in autophagy regulation. PTPRS expressed on plasmacytoid dendritic cells (pDCs) inhibits the production of type I interferon (IFN) in response to viruses. Mutation of both Ptprs and Ptprf (protein tyrosine phosphatasereceptor type F) results in pDC hyperactivation and mild colitis.