52-88-0

mp 162-164 C

Methylatropine,Paganfarma

antibacterial

cephalosporin antimicrobial

There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at 110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl atropine chloride and silver nitrate) in water was added aqueous solution of 26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was concentrated and the methyl atropine nitrate was obtained.

Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).

Anticholinergic, Mydriatic, Spasmolytic

Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.