ChemicalBook CAS DataBase List 51116-01-9

51116-01-9

Name	8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
CAS	51116-01-9
EINECS(EC#)	256-993-8
Molecular Formula	C10H10BrN5O7P.Na
MDL Number	MFCD03703483
Molecular Weight	446.08
MOL File	51116-01-9.mol

Synonyms

BR-CGMP, NA 8-BR-CGMP NA 8-BROMO-CGMP NA Einecs 256-993-8 8-BROMO-CGMP SODIUM 8-BR-CGMP SODIUM SALT (115974-70-4) 8-AET-cGMP 8-BROMO-CGMP, SODIUM SALT 8-bromo-Cyclic GMP (sodium salt) 8-BROMOGUANOSINE-3',5'-CYCLOPHOSPHATE SODIUM 8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5 8-bromoguanosine 3:5-cyclic*monophosphate sodiu 8-BROMOGUANOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT 8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM 8-Bromoguanosine-3,5-cyclomonophosphate sodium salt 8-BROMOGUANOSINE CYCLIC 3',5'-MONOPHOSPHATE SODIUM SALT 8-BROMOGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT 8-BROMOGUANOSINE-3,5-CYCLICMONOPHOSPHATESODIUMSALT,ULTRAPURE 8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt, 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt Guanosine 3,5-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem

Chemical Properties

storage temp.	-20°C
solubility	H₂O: 100 mg/mL
form	powder
color	White to off-white
Water Solubility	Soluble to 100 mM in water
InChIKey	ZJRFCXHKYQVNFK-YEOHUATISA-M
SMILES	[Na+].NC1=Nc2c(nc(Br)n2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1

Safety Data

WGK Germany	3
F	10-21
HS Code	29349990
Storage Class	11 - Combustible Solids

Hazard Information

Description

8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Chemical Properties

White powder

Uses

8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Definition

ChEBI: Sodium 8-bromo-3',5'-cyclic GMP is an organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a protein kinase G agonist and a muscle relaxant. It contains an 8-bromo-3',5'-cyclic GMP(1-).

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .

storage

Desiccate at -20°C

References

[1] S S RASHATWAR T M L T L Cornwell. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 16: 5685-5689. DOI: 10.1073/pnas.84.16.5685
[2] J CHOI J M F. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells.[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 285 2: 588-594.

Spectrum Detail

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Telephone400-6206333 13167063860

Websitehttp://www.aladdin-e.com/

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Telephone+86-400-002-6226

Websitehttps://www.rrkchem.com

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

NewCan Biotech Limited

Telephone+86-571-86912261 19975279805

Websitehttps://www.newcanbio.com/

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

cjbscvictory

Telephone13348960310 13348960310

Websitehttps://www.weikeqi-biotech.com/

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

Kaifeng Mingren Pharmaceutical Co.,LTD

Telephone0371-65741762

Websitehttps://www.kfmryy.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Beijing Qinling Pharmaceutical Co., Ltd.

Telephone010-61241352 18901327973

Websitehttp://www.qlmed.com/

Shanghai Yingxin laboratory equipment Co., Ltd

Telephone021-021-59178156 15300768757

Websitehttp://www.yingxinbio.com/

Shanghai Guchen Biotechnology Co., LTD

Telephone021-34675735 19147740836

Websitehttp://www.shgcsw-edu.com

1of4

Related Products

Send Inquriy