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1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E₂ (PGE₂; ) in normal human epidermal keratinocytes (NHEKs). 1-O-Hexadecyl-sn-glycerol (50 μM) increases coronary flow and left ventricular developed pressure and reduces malondialdehyde (MDA) formation ex vivo in a rat heart model of ischemia/reperfusion injury.

1-O-Hexadecyl-sn-glycerol restores plasmalogen levels in Chinese hamster ovary (CHO) cells and human pulmonary arterial endothelial cells (PAEC). Plasmalogen may play a role in protecting animal cells against photosensitized killing.

ChEBI: A 1-n-hexadecyl analogue of an optically active alkylglycerol compound.

Recrystallise it from hexane. [Beilstein 1 III 2322.]

[1] MARIKO YOKOTA. Chimyl Alcohol Suppresses PGE2 Synthesis by Human Epidermal Keratinocytes through the Activation of PPAR-γ.[J]. Journal of oleo science, 2018, 67 4: 455-462. DOI: 10.5650/jos.ess17157
[2] N MAULIK. Myocardial salvage by chimyl alcohol: possible role of peroxisomal dysfunction in reperfusion injury.[J]. Annals of the New York Academy of Sciences, 1994, 723: 380-384.