ChemicalBook CAS DataBase List 5002-47-1

5002-47-1

Name	Fluphenazine decanoate
CAS	5002-47-1
EINECS(EC#)	225-672-4
Molecular Formula	C32H44F3N3O2S
MDL Number	MFCD00798504
Molecular Weight	591.77
MOL File	5002-47-1.mol

Synonyms

lyogen modecate sq10,733 dapotumd ecanoate moditendepot zinyl)ethylester prolixindecanoate fluphenazinedepot flufenazinedecanoate FLUPHENAZINEDECANATE FluphenazineCecanoate FLUPHENAZINE DECANOATE fluphenazine o-decanoate fluorophenazinedecanoate Decanoic acid fluphenazine 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyld decanoicacid,2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-pipera 2-[4-[3-(2-(TRIFLUOROMETHYL)PHENOTHIAZIN-10-YL)PROPYL]PIPERAZIN-1-YL]ETHYL DECANOATE 2-(4-(3-(2-(trifluoroMethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl decanoate Decanoic acid 2-[4-[3-(2-trifluoromethyl-10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethyl ester Decanoic acid, 2-[4-[3-[2-(trifluoromethyl) -10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester

Chemical Properties

Melting point	30-32°
Boiling point	658.1±55.0 °C(Predicted)
density	1.149±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
form	neat
pka	7.32±0.10(Predicted)
CAS DataBase Reference	5002-47-1

Safety Data

RIDADR	3249
RTECS	HE0525000
HazardClass	6.1(a)
PackingGroup	II

Hazard Information

Chemical Properties

Yellow Oil

Uses

Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.

Definition

ChEBI:Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It is functionally related to a fluphenazine.

Clinical Use

Antipsychotic
Schizophrenia and other psychoses

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids.
Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval; increased risk of ventricular arrhythmias with amiodarone and dronedarone - avoid; increased risk of ventricular arrhythmias with disopyramide.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid
Antidepressants: increased risk of ventricular arrhythmias with tricyclics, citalopram, escitalopram; possible increased risk of convulsions with vortioxetine
Antiepileptics: antagonises anticonvulsant effect.
Antimalarials: increased risk of ventricular arrhythmias with artenimol with piperaquine and artemether/lumefantrine - avoid.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol, pimozide and risperidone - avoid; avoid use of depot formulations with clozapine (cannot be withdrawn quickly if neutropenia occurs).
Antivirals: increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased with ritonavir.
Anxiolytics and hypnotics: increased sedative effects
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias - avoid.
Avoid with drugs that prolong the QT interval.

Metabolism

The cytochrome P450 isoenzyme CYP2D6 is involved in fluphenazine metabolism.

storage

Store at -20°C

Supplier

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