496801-51-5

OH-C-Chol is a cationic cholesterol derivative. OH-C-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver.

OH-C-Chol is a cationic liposome that serves as a siRNA delivery vehicle. OH-C-Chol (LP-C) and OH-NC-Chol (LP-NC)/siRNA complexes (lipoplexes) showed better performance than NP-C and NP-NC/siRNA complexes (nanocomplexes), respectively. ) greater gene silencing effect[1].

[1] Hattori Y, et al. siRNA delivery into tumor cells by cationic cholesterol derivative-based nanoparticles and liposomes. Biol Pharm Bull. 2015;38(1):30-8. DOI:10.1248/bpb.b14-00526