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MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in MHAPC-chol accumulation in the liver.

MHAPC-Chol, a cationic cholesterol, results in a high gene silencing effect via high cellular association. MHAPC-Chol delivers siRNA to the liver[1].

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[1] Yoshiyuki Hattori, et al. Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex. J Drug Target. 2019 Feb;27(2):217-227.