191173-82-7

OH-Chol is a cationic cholesterol derivative. OH-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG₂₀₀₀-DSPE in a KB mouse xenograft model for intratumoral gene delivery.

OH-Chol is a cationic cholesterol derivative. OH-Chol can be used for siRNA delivery and gene silencing[1].

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[1] Seong Ho Hong, et al. Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation. bioRxiv [Preprint]. 2023 Nov 2:2023.10.20.563371. DOI:10.1101/2023.10.20.563371