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Radiprodil could block NMDA currents in Mg²⁺ insensitive variants, with potencies similar to those obtained without Mg^2+[3].
Radiprodil's potency is higher at pH 7.0 than at pH 7.6, suggesting that radiprodil may retain its ability to block glutamate-induced NMDA currents even under acidic conditions that manifest under long term seizures^[3].