478-35-3

Carviolin is an anthraquinone fungal metabolite that has been found in Z. longicaudata with immunosuppressive and antitrypanosomal activities. It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC₅₀s = 4 and 4.5 μg/ml, respectively). Carviolin is active against T. b. brucei (MIC = 41.66 μM).

Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities[1].

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[1] Eilbert F, et al. Neobulgarones A approximately F from cultures of Neobulgaria pura, new inhibitors of appressorium formation of Magnaporthe grisea. J Antibiot (Tokyo). 2000;53(10):1123-1129. DOI:10.7164/antibiotics.53.1123