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Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2].

ChEBI: Pinocembrin chalcone is a member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 4' and 6' respectively. It has a role as a plant metabolite and an antifungal agent. It is functionally related to a trans-chalcone.

[1] P D Bremner, et al. Pinocembrin Chalcone: An Antibacterial Compound From Helichrysum Trilineatum. Planta Med. 1998 Dec;64(8):777. DOI:10.1055/s-2006-957585
[2] Shin J, et al. Antidiabetic effects of trihydroxychalcone derivatives via activation of AMP-activated protein kinase[J]. Journal of Industrial and Engineering Chemistry, 2018, 60: 177-184.