41520-73-4

Tetrahydropteroylpentaglutamate exhibits strong product inhibition by H4PteGlu5. In vivo, this enzyme may bind significant amounts of this coenzyme in a nearly irreversible enzyme.

Tetrahydropteroylpentaglutamate (H4PteGlu5) is an inhibitor for 10-CHO-THF dehydrogenase with a Kd of 20 nM through binding of an irreversible o 10-CHO-THF dehydrogenase-H4PteGlu5 complex[1].

[1] Kim DW, et al., Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase. Biochemistry. 1996 Dec 10;35(49):15772-83. DOI:10.1021/bi9619684