41059-79-4

Induces autophagy in HeLa cells followed by apoptotic cell death (IC50=10μM). This cellular response has been found to be mediated via inhibition of mTORC1 and induction of ER stress (IC50 for BT474 cells=2.5μM and MDAMB231 cells=6μM). The pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.