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• Structure

  Organic compounds containing the tri­fluoro­methyl (CF3) or penta­fluoro­thio (or penta­fluoro-λ6-sulfanyl, SF5) groups play an important role in organofluorine chemistry because of their special properties, including low surface energy, hydro­phobicity, high chemical resistance, high thermal stability and high electronegativity. SF5, coined as the ‘super-tri­fluoro­meth­yl’ group, is often preferred to CF3 as it is more electronegative, lipophilic and chemically stable and possesses a higher steric effect. The current inter­est in the drug discovery of fluorinated substituents is based on the possibility of improving both the metabolic stability and bioavailability of receptor binders upon the incorporation of substituents with one or more fluorine atoms. Several blockbuster drugs include such a group, demonstrating the prominent role of the tri­fluoro­methyl group in the area of drug discovery. New mol­ecules incorporating the SF5 group are thus potential alternatives to already existing biologically active mol­ecules containing the CF3 substitution[1].;

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