Tiplaxtinin(393105-53-8) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC
50 = 2.7 μM for the human enzyme).
1 It inhibits differentiation of human adipocytes when used at a concentration of 5 μM.
2 Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model.
3 It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.
4