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Ecopladib is orally efficacious in this model and displays an ED₅₀ of 8 mg/kg, demonstrating that it can inhibit COX-2 derived PGE2 formation in vivo. Ecopladib is orally efficacious at reducing carrageenan-induced paw swelling:?from dose?response studies, it is determined that the ED₅₀ is 40 mg/kg^[1].