37936-89-3

(S)-Norfenfluramine Hydrochloride is a metabolite of (S)-(+)-Fenfluramine Hydrochloride (F247596); an anorexic.

(+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood; acts primarily on the cytoplasmic pool of serotonin; more potent than fenfluramine at inducing dopamine release.

5-HT_2B Receptor: 11.2 nM (Ki); 5-HT_2C Receptor: 324 nM (Ki); 5-HT_2A Receptor: 1516 nM (Ki)