36798-79-5

Budralazine is an antihypertensive agent which is somewhat less potent than structurally related hydralazine, and reportedly produces less tachycardia.

Daiichi (Japan)

Budralazine a new antihypertensive agent. Budralazine is a direct-acting vasodilator.

ChEBI: Budralazine is a member of phthalazines.

A mixture of 2.0 g of 1-hydrazinophthalazine hydrochloride, 1.1 g of mesityl oxide (isoproplyideneacetone) and 100 ml of ethanol, was refluxed for 3 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in water. The water solution was neutralized with sodium bicarbonate, salted out and the product was extracted with benzene. The benzene layer was passed through a comparatively short column of alumina and the solvent was removed. The residue was crystallized from ether to give 0.7 g of 1-(1,3-dimethyl-2-butenylidene) hydrazinophthalazine, melting point 131°-132°C.

BUTERAZINE

Antihypertensive