36614-32-1

Prostaglandin B₃ (PGB₃) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E₃ (PGE₃) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB₃ exhibited a K_i value greater than 1 mM. In contrast, PGB₁ and PGB₂ showed significantly higher affinity for PPARγ, with K_i values of 26 and 77 μM, respectively, the same assay.