364-73-8

1493-27-2

364-73-8

General procedure for the synthesis of 4-bromo-1-fluoro-2-nitrobenzene from 1-fluoro-2-nitrobenzene: After completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into ice water. The product 2-fluoro-5-bromonitrobenzene in the aqueous phase was extracted with 200 mL of ethyl acetate, and the organic phases were combined and concentrated under reduced pressure to give a brown solid crude product. The crude product was purified by recrystallization from petroleum ether and analyzed by gas chromatography (GC) with a purity of 98%, and 227.1 g of the pure product was obtained after drying with a yield of 40.0%.