363600-92-4

TLR2-IN-29 is a inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targetingselective toll-like receptor 2 (TLR2) antagonist th at inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signalrespectivelyusing HEK293T TLR2/6 or TLR2/1 transfectants)while blocking only murine TLR2/1-but not murine TLR2/6-mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages)nor signaling induced by other TLR agonists and TNF-α.