362703-34-2

362703-33-1

24424-99-5

362703-34-2

The general procedure for the synthesis of methyl N-Boc-4-cyanopiperidine-4-carboxylate from the compound (CAS: 362703-33-1) and di-tert-butyl dicarbonate was as follows: piperidine (640 mg, 2.11 mmol) from reaction (24a), di-tert-butyl dicarbonate (500 mg, 2.3 mmol) and a catalytic amount of palladium hydroxide were dissolved in ethyl acetate ( 10 mL). The hydrogenation reaction was carried out under hydrogen atmosphere at 1 atmosphere. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was subsequently concentrated to afford the target product methyl N-Boc-4-cyanopiperidine-4-carboxylate (566 mg, 100% yield). Mass spectral analysis showed (M + H)+ = 269.